Journal article

Evolution of atypical enteropathogenic E. coli by repeated acquisition of LEE pathogenicity island variants

Danielle J Ingle, Marija Tauschek, David J Edwards, Dianna M Hocking, Derek J Pickard, Kristy I Azzopardi, Thakshila Amarasena, Vicki Bennett-Wood, Jaclyn S Pearson, Boubou Tamboura, Martin Antonio, John B Ochieng, Joseph Oundo, Inacio Mandomando, Shahida Qureshi, Thandavarayan Ramamurthy, Anowar Hossain, Karen L Kotloff, James P Nataro, Gordon Dougan Show all



Atypical enteropathogenic Escherichia coli (aEPEC) is an umbrella term given to E. coli that possess a type III secretion system encoded in the locus of enterocyte effacement (LEE), but lack the virulence factors (stx, bfpA) that characterize enterohaemorrhagic E. coli and typical EPEC, respectively. The burden of disease caused by aEPEC has recently increased in industrialized and developing nations, yet the population structure and virulence profile of this emerging pathogen are poorly understood. Here, we generated whole-genome sequences of 185 aEPEC isolates collected during the Global Enteric Multicenter Study from seven study sites in Asia and Africa, and compared them with publicly av..

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Awarded by Australian NHMRC

Awarded by Wellcome Trust

Awarded by Bill & Melinda Gates Foundation

Awarded by Victorian Life Sciences Computation Initiative

Awarded by Medical Research Council

Funding Acknowledgements

This work was funded by the Australian NHMRC (project grant nos. 1009296 and 1067428 to R.M.R.-B., fellowship no. 1061409 to K.E.H.), the Wellcome Trust (grant no. 098051 to the Wellcome Trust Sanger Institute, WTSI), the Bill & Melinda Gates Foundation (grant ID no. 38874 to M.M.L.) and the Victorian Life Sciences Computation Initiative (grant no. VR0082). The authors thank the sequencing teams at the WTSI for genome sequencing.