Hippocampal malrotation is an anatomic variant and has no clinical significance in MRI-negative temporal lobe epilepsy

Meng-Han Tsai; David N Vaughan; Yuliya Perchyonok; Greg J Fitt; Ingrid E Scheffer; Samuel F Berkovic; Graeme D Jackson

Journal article

Hippocampal malrotation is an anatomic variant and has no clinical significance in MRI-negative temporal lobe epilepsy

Meng-Han Tsai, David N Vaughan, Yuliya Perchyonok, Greg J Fitt, Ingrid E Scheffer, Samuel F Berkovic, Graeme D Jackson

EPILEPSIA | WILEY-BLACKWELL | Published : 2016

DOI: 10.1111/epi.13505

Abstract

OBJECTIVE: There is considerable difficulty in diagnosing hippocampal malrotation (HIMAL), with different criteria of variable reliability. Here we assess qualitative and quantitative criteria in HIMAL diagnosis and explore the role of HIMAL in magnetic resonance imaging (MRI)-negative temporal lobe epilepsy (TLE). METHODS: We studied the MRI of 155 adult patients with MRI-negative TLE and 103 healthy volunteers, and we asked (1) what are the qualitative and quantitative features that allow a reliable diagnosis of HIMAL, (2) how common is HIMAL in a normal control population, and (3) is HIMAL congruent with the epileptogenic side in MRI-negative TLE. RESULTS: We found that the features that ..

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University of Melbourne Researchers

Saul Mullen Author Medical Education

Ingrid Scheffer Author Medicine - Austin Health

David Vaughan Author Florey Department of Neuroscience and Mental Health

Graeme Jackson Author Florey Department of Neuroscience and Mental Health

Sam Berkovic Author Medicine - Austin Health

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by NHMRC

Funding Acknowledgements

This study was supported by the National Health and Medical Research Council (NHMRC) of Australia (program grant 628952; project grant 628725) and the Victorian Government Operational Infrastructure Support Program. G Jackson is supported by an NHMRC Practitioner Fellowship (1060312).