Antifungal susceptibilities of non-Aspergillus filamentous fungi causing invasive infection in Australia: support for current antifungal guideline recommendations

CL Halliday; SCA Chen; SE Kidd; S van Hal; B Chapman; CH Heath; A Lee; KJ Kennedy; K Daveson; TC Sorrell; CO Morrissey; DJ Marriott; MA Slavin

Journal article

Antifungal susceptibilities of non-Aspergillus filamentous fungi causing invasive infection in Australia: support for current antifungal guideline recommendations

CL Halliday, SCA Chen, SE Kidd, S van Hal, B Chapman, CH Heath, A Lee, KJ Kennedy, K Daveson, TC Sorrell, CO Morrissey, DJ Marriott, MA Slavin

International Journal of Antimicrobial Agents | ELSEVIER SCIENCE BV | Published : 2016

DOI: 10.1016/j.ijantimicag.2016.07.005

Abstract

Antifungal susceptibilities of non-Aspergillus filamentous fungal pathogens cannot always be inferred from their identification. Here we determined, using the Sensititre® YeastOne® YO10 panel, the in vitro activities of nine antifungal agents against 52 clinical isolates of emergent non-Aspergillus moulds representing 17 fungal groups in Australia. Isolates comprised Mucorales (n = 14), Scedosporium/Lomentospora spp. (n = 18) and a range of hyaline hyphomycetes (n = 9) and other dematiaceous fungi (n = 11). Excluding Verruconis gallopava, echinocandins demonstrated poor activity (MICs generally >8 mg/L) against these moulds. Lomentospora prolificans (n = 4) and Fusarium spp. (n = 6) demonstr..

View full abstract