Antifungal susceptibilities of non-Aspergillus filamentous fungi causing invasive infection in Australia: support for current antifungal guideline recommendations

Catriona L Halliday; Sharon C-A Chen; Sarah E Kidd; Sebastian van Hal; Belinda Chapman; Christopher H Heath; Andie Lee; Karina J Kennedy; Kathryn Daveson; Tania C Sorrell; C Orla Morrissey; Deborah J Marriott; Monica A Slavin

Journal article

Antifungal susceptibilities of non-Aspergillus filamentous fungi causing invasive infection in Australia: support for current antifungal guideline recommendations

Catriona L Halliday, Sharon C-A Chen, Sarah E Kidd, Sebastian van Hal, Belinda Chapman, Christopher H Heath, Andie Lee, Karina J Kennedy, Kathryn Daveson, Tania C Sorrell, C Orla Morrissey, Deborah J Marriott, Monica A Slavin

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | ELSEVIER SCIENCE BV | Published : 2016

DOI: 10.1016/j.ijantimicag.2016.07.005

Abstract

Antifungal susceptibilities of non-Aspergillus filamentous fungal pathogens cannot always be inferred from their identification. Here we determined, using the Sensititre(®) YeastOne(®) YO10 panel, the in vitro activities of nine antifungal agents against 52 clinical isolates of emergent non-Aspergillus moulds representing 17 fungal groups in Australia. Isolates comprised Mucorales (n = 14), Scedosporium/Lomentospora spp. (n = 18) and a range of hyaline hyphomycetes (n = 9) and other dematiaceous fungi (n = 11). Excluding Verruconis gallopava, echinocandins demonstrated poor activity (MICs generally >8 mg/L) against these moulds. Lomentospora prolificans (n = 4) and Fusarium spp. (n = 6) demo..

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