Cystatin C, chronic kidney disease and retinopathy in adults without diabetes

Abstract

Background Serum cystatin C, a novel marker of renal function has been shown to be superior to serum creatinine in predicting renal function decline and adverse outcomes of chronic kidney disease (CKD). Our aim was to investigate the association between cystatin C and retinopathy in adults without diabetes. Methods We examined 1725 Indian adults, aged 40-80 years who participated in the Singapore Indian Eye Study (2007-2009) and were free of diabetes mellitus. CKD was defined as an estimated glomerular filtration rate (EGFR) <60 ml/min/1.73 m2 determined from serum cystatin C (CKD-EGFRcys, n = 199), and serum creatinine (CKD-EGFRcr, n = 81). Retinopathy was assessed from digital fundus photo..