Low genetic diversity among historical and contemporary clinical isolates of felid herpesvirus 1
Paola K Vaz, Natalie Job, Jacquelyn Horsington, Nino Ficorilli, Michael J Studdert, Carol A Hartley, James R Gilkerson, Glenn F Browning, Joanne M Devlin
BMC GENOMICS | BIOMED CENTRAL LTD | Published : 2016
BACKGROUND: Felid herpesvirus 1 (FHV-1) causes upper respiratory tract diseases in cats worldwide, including nasal and ocular discharge, conjunctivitis and oral ulceration. The nature and severity of disease can vary between clinical cases. Genetic determinants of virulence are likely to contribute to differences in the in vivo phenotype of FHV-1 isolates, but to date there have been limited studies investigating FHV-1 genetic diversity. This study used next generation sequencing to compare the genomes of contemporary Australian clinical isolates of FHV-1, vaccine isolates and historical clinical isolates, including isolates that predated the introduction of live attenuated vaccines into Aus..View full abstract
Related Projects (3)
Awarded by Australian Research Council
Awarded by ARC
The Australian Research Council (ARC DP130103991) and the Feline Health Research Fund supported this work. JMD is supported by ARC FT140101287.