Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function
Emilio P Mottillo, Eric M Desjardins, Justin D Crane, Brennan K Smith, Alex E Green, Serge Ducommun, Tora I Henriksen, Irena A Rebalka, Aida Razi, Kei Sakamoto, Camilla Scheele, Bruce E Kemp, Thomas J Hawke, Joaquin Ortega, James G Granneman, Gregory R Steinberg
Cell Metabolism | CELL PRESS | Published : 2016
We thank Marcia Reid for technical assistance in sample preparation for EM and Rick McKenzie for advice in de-noising filters. We acknowledge Dr. John Rubinstein and the Hospital for Sick Children in Toronto for allowing access to the EM Facility. We thank Julian Yabut for technical assistance with genotyping and cell culture and Dr. Matthew J. Watt (Monash University) for providing ATGL antibodies. These studies were supported by grants from the Canadian Diabetes Association (G.R.S.), the Canadian Institutes of Health Research (G.R.S.), the Natural Sciences and Engineering Research Council of Canada (G.R.S.), and the National Health and Medical Research Council of Australia (G.R.S. and B.E.K.). E.P.M. is a Canadian Diabetes Association Post-doctoral Fellow. E.M.D. is a recipient of an Ontario Graduate Scholarship and Queen Elizabeth II Graduate Scholarship in Science and Technology. B.K.S. is a recipient of a CIHR post-doctoral fellowship. C.S. was supported by the Novo Nordisk Foundation. T.I.H. was supported by a PhD scholarship from Faculty of Health Sciences, University of Copenhagen. CFAS is supported by Trygfonden. The Novo Nordisk Foundation Center for Basic Metabolic Research (http://www.metabol.ku.dk) is supported by an unconditional grant from the Novo Nordisk Foundation to University of Copenhagen. A.E.G. is a recipient of a CIHR/MitoCanada Doctoral Research Award. G.R.S. is a Canada Research Chair in Metabolism and Obesity and the J. Bruce Duncan Chair in Metabolic Diseases.