Journal article
Is there a march from early food sensitization to later childhood allergic airway disease? Results from two prospective birth cohort studies
SA Alduraywish, M Standl, CJ Lodge, MJ Abramson, KJ Allen, B Erbas, A von Berg, J Heinrich, AJ Lowe, SC Dharmage
Pediatric Allergy and Immunology | WILEY | Published : 2017
DOI: 10.1111/pai.12651
Abstract
Background: The march from early aeroallergen sensitization to subsequent respiratory allergy is well established, but it is unclear whether early life food sensitization precedes and further increases risk of allergic airway disease. Objective: To assess the association between food sensitization in the first 2 years of life and subsequent asthma and allergic rhinitis by age 10–12 years. Methods: We used data from two independent cohorts: the high-risk Melbourne Atopic Cohort Study (MACS) (n = 620) and the population-based LISAplus (n = 3094). Food sensitization was assessed at 6, 12, and 24 months in MACS and 24 months in LISAplus. Multiple logistic regressions were used to estimate associ..
View full abstractGrants
Funding Acknowledgements
SAA has scholarship from King Saud University, Riyadh-Saudi Arabia represented by Saudi Arabian Cultural Mission in Canberra, Australia; CJL is funded by The National Health and Medical Research Council of Australia (NHMRC); AJL and SCD are funded by the NHMRC; KJA is funded by the Charles and Sylvia Viertel Charitable Foundation. MJA holds investigator-initiated research grants from Pfizer and Boehringer Ingelheim. He received support to attend the ERS Congress from Boehringer Ingelheim and attended a Respiratory Symposium funded by Novartis. He has been paid honoraria by Astra Zeneca and Novartis. These do not constitute substantial sources of income. BE, MS, AB, and JH have no personal funding relationships to declare.Initial funding for the MACS in the first six years of the study was from Nestec (a subsidiary of Nestle Australia). The 12-year follow-up was supported by the Asthma Foundation of Victoria. The funding bodies had no role in the study design, collection, analysis, or interpretation of data, nor in writing this report or the decision to publish. The results, conclusions, and opinions reported in the manuscript are those of the authors and are independent from the funding sources.The LISAplus study was mainly supported by grants from the Federal Ministry for Education, Science, Research and Technology and in addition from Helmholtz Zentrum Munich (former GSF), Helmholtz Centre for Environmental Research-UFZ, Leipzig, Research Institute at Marien-Hospital Wesel, Pediatric Practice, Bad Honnef, for the first 2 years. The 4-year, 6-year, and 10-year follow-up examinations of the LISAplus study were covered from the respective budgets of the involved partners (Helmholtz Zentrum Munich (former GSF), Helmholtz Centre for Environmental Research-UFZ, Leipzig, Research Institute at Marien-Hospital Wesel, Pediatric Practice, Bad Honnef, IUF-Leibniz Research Institute for Environmental Medicine at the University of Dusseldorf) and in addition by a grant from the Federal Ministry for Environment (IUF Dusseldorf, FKZ 20462296).