Journal article
Performance on the Cogstate Brief Battery Is Related to Amyloid Levels and Hippocampal Volume in Very Mild Dementia
YY Lim, VL Villemagne, SM Laws, RH Pietrzak, D Ames, C Fowler, S Rainey-Smith, PJ Snyder, P Bourgeat, RN Martins, O Salvado, CC Rowe, CL Masters, P Maruff, undefined on behalf of the AIBL Research Group
Journal of Molecular Neuroscience | HUMANA PRESS INC | Published : 2016
Abstract
In a group of older adults with very mild dementia, we aimed to characterize the nature and magnitude of cognitive decline as measured by the Cogstate Brief Battery, in relation to Aβ levels and hippocampal volume. Participants were characterized according to their status on the Clinical Dementia Rating (CDR) scale. A total of 308 individuals who were CDR 0 and had low cerebral Aβ levels (Aβ−), 32 individuals who were Aβ− and CDR 0.5, and 43 individuals who were Aβ+ and CDR 0.5 were included in this study. Participants completed the CogState brief battery at baseline, and at 18-, 36-, 54- and 72-month follow-up. Linear mixed model analyses indicated that relative to the Aβ− CDR 0 group, the ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
Funding for the study was provided in part by the study partners [Commonwealth Scientific Industrial and research Organization (CSIRO), Edith Cowan University (ECU), Mental Health Research institute (MHRI), National Ageing Research Institute (NARI) and Austin Health, CogState Ltd.]. The study also received support from the National Health and Medical Research Council (NHMRC) and the Dementia Collaborative Research Centres program (DCRC2), as well as funding from the Science and Industry Endowment Fund (SIEF) and the Cooperative Research Centre (CRC) for Mental Health, an Australian Government Initiative. YYL is currently funded by the National Health & Medical Research Council-Australian Research Council (NHMRC-ARC) Dementia Research Development Fellowship (APP1111603).