Journal article
Early gut colonization by Bifidobacterium breve and B. catenulatum differentially modulates eczema risk in children at high risk of developing allergic disease
IH Ismail, RJ Boyle, PV Licciardi, F Oppedisano, S Lahtinen, RM Robins-Browne, MLK Tang
Pediatric Allergy and Immunology | WILEY | Published : 2016
DOI: 10.1111/pai.12646
Abstract
Background: An altered compositional signature and reduced diversity of early gut microbiota are linked to development of allergic disease. We investigated the relationship between dominant Bifidobacterium species during the early post-natal period and subsequent development of allergic disease in the first year of life. Methods: Faecal samples were collected at age 1 week, 1 month and 3 months from 117 infants at high risk of allergic disease. Bifidobacterium species were analysed by quantitative PCR and terminal restriction fragment length polymorphism. Infants were examined at 3, 6 and 12 months, and skin prick test was performed at 12 months. Eczema was diagnosed according to the UK Work..
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Funding Acknowledgements
The studies were funded by grants from the Jack Brockhoff Foundation, the Murdoch Childrens Research Institute and the Ilhan Food Allergy Foundation. Intan Hakimah Ismail was supported by a scholarship from the Ministry of Higher Education, Malaysia, and Universiti Putra Malaysia. Robert Boyle was supported by a University of Melbourne Baillieu Scholarship, a Murdoch Childrens Research Institute Postgraduate Scholarship and a National Institute for Health Research Comprehensive Biomedical Research Centre. Paul V Licciardi is a recipient of an NHMRC Early Career Fellowship. The Murdoch Childrens Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. LGG and placebo capsules were manufactured and supplied by Dicofarm ltd (Roma, Italy).