Improving Targeting of Metal-Phenolic Capsules by the Presence of Protein Coronas
Yi Ju, Qiong Dai, Jiwei Cui, Yunlu Dai, Tomoya Suma, Joseph J Richardson, Frank Caruso
ACS APPLIED MATERIALS & INTERFACES | AMER CHEMICAL SOC | Published : 2016
Particles adsorb proteins when they enter a physiological environment; this results in a surface coating termed a "protein corona". A protein corona can affect both the properties and functionalities of engineered particles. Here, we prepared hyaluronic acid (HA)-based capsules through the assembly of metal-phenolic networks (MPNs) and engineered their targeting ability in the absence and presence of protein coronas by varying the HA molecular weight. The targeting ability of the capsules was HA molecular weight dependent, and a high HA molecular weight (>50 kDa) was required for efficient targeting. The specific interactions between high molecular weight HA capsules and receptor-expressing ..View full abstract
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Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology
Awarded by ARC
This work was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (project CE140100036). This work was also supported by the ARC under the Australian Laureate Fellowship (F.C., FL120100030) scheme. This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at the University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF).