Journal article
P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age
MEC Waaijer, DA Gunn, PD Adams, JS Pawlikowski, CEM Griffiths, D Van Heemst, PE Slagboom, RGJ Westendorp, AB Maier
Journals of Gerontology Series A Biological Sciences and Medical Sciences | OXFORD UNIV PRESS INC | Published : 2016
Abstract
Senescent cells are more prevalent in aged human skin compared to young, but evidence that senescent cells are linked to other biomarkers of aging is scarce. We counted cells positive for the tumor suppressor and senescence associated protein p16INK4a in sun-protected upper-inner arm skin biopsies from 178 participants (aged 45-81 years) of the Leiden Longevity Study. Local elastic fiber morphology, facial wrinkles, and perceived facial age were compared to tertiles of p16INK4a counts, while adjusting for chronological age and other potential confounders. The numbers of epidermal and dermal p16INK4a positive cells were significantly associated with age-associated elastic fiber morphologic ch..
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Awarded by Unilever
Funding Acknowledgements
This study was supported by the Innovation Oriented research Program on Genomics (SenterNovem; IGE01014, IGE5007), the Centre for Medical Systems Biology (CMSB), the Netherlands Genomics Initiative/Netherlands Organization for Scientific Research (NGI/NWO 05040202, 050-060-810 [NCHA]), Unilever, the EU funded Network of Excellence Lifespan (FP6 036894), and the National Institute on Aging (NIA P01 AG031862). Individual coauthors were funded by the Netherlands Genomics Initiative (NCHA 050-060-810 to P.E.S.) and T32HL007751-NIH Training Grant in Mechanisms of Vascular Disease (J.S.P.).