Neural correlates of cough hypersensitivity in humans: evidence for central sensitisation and dysfunctional inhibitory control
Ayaka Ando, David Smallwood, Marcus McMahon, Louis Irving, Stuart B Mazzone, Michael J Farrell
THORAX | BMJ PUBLISHING GROUP | Published : 2016
INTRODUCTION: Chronic non-productive coughing is a major complication of pulmonary disease and can also occur in many individuals without identifiable underlying pathology. The common clinical link in patients with cough is an enhanced sensitivity of the respiratory system to stimuli that subsequently evoke excessive coughing. The aetiology of this 'cough hypersensitivity syndrome' is unclear but believed to involve hypersensitivity of the sensory neural pathways that innervate the airways and lungs. METHODS: In the present study, we used functional brain imaging to compare central neural responses to airway stimulation using inhaled capsaicin in healthy people and patients with cough hypers..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
This research was supported by grants to SBM and MJF from the National Health and Medical Research Council (NHMRC) of Australia (1042528, 1025589, 1078943).