Journal article
Uncovering cortico-striatal correlates of cognitive fatigue in pediatric acquired brain disorder: Evidence from traumatic brain injury
NP Ryan, MH Beauchamp, R Beare, L Coleman, M Ditchfield, M Kean, TJ Silk, S Genc, C Catroppa, VA Anderson
Cortex | ELSEVIER MASSON, CORPORATION OFFICE | Published : 2016
Abstract
Cognitive fatigue is among the most profound and disabling sequelae of pediatric acquired brain disorders, however the neural correlates of these symptoms in children remains unexplored. One hypothesis suggests that cognitive fatigue may arise from dysfunction of cortico-striatal networks (CSNs) implicated in effort output and outcome valuation. Using pediatric traumatic brain injury (TBI) as a model, this study investigated (i) the sub-acute effect of brain injury on CSN volume; and (ii) potential relationships between cognitive fatigue and sub-acute volumetric abnormalities of the CSN. 3D T1 weighted magnetic resonance imaging sequences were acquired sub-acutely in 137 children (TBI: n = 1..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
All phases of this study were supported in part by a National Health and Medical Research Council Moving Ahead Seed Grant (Nicholas Ryan, awarded 2014); a grant from the Victoria Neurotrauma Initiative, Australia; and the Victorian Government Operational Infrastructure Support Program (No. CO6E1).