When do myopia genes have their effect? Comparison of genetic risks between children and adults

J Willem L Tideman; Qiao Fan; Jan Roelof Polling; Xiaobo Guo; Seyhan Yazar; Anthony Khawaja; Rene Hoehn; Yi Lu; Vincent WV Jaddoe; Kenji Yamashiro; Munemitsu Yoshikawa; Aslihan Gerhold-Ay; Stefan Nickels; Tanja Zeller; Mingguang He; Thibaud Boutin; Goran Bencic; Veronique Vitart; David A Mackey; Paul J Foster; Stuart MacGregor; Cathy Williams; Seang Mei Saw; Jeremy A Guggenheim; Caroline CW Klaver

Journal article

When do myopia genes have their effect? Comparison of genetic risks between children and adults

J Willem L Tideman, Qiao Fan, Jan Roelof Polling, Xiaobo Guo, Seyhan Yazar, Anthony Khawaja, Rene Hoehn, Yi Lu, Vincent WV Jaddoe, Kenji Yamashiro, Munemitsu Yoshikawa, Aslihan Gerhold-Ay, Stefan Nickels, Tanja Zeller, Mingguang He, Thibaud Boutin, Goran Bencic, Veronique Vitart, David A Mackey, Paul J Foster Show all

GENETIC EPIDEMIOLOGY | WILEY-BLACKWELL | Published : 2016

DOI: 10.1002/gepi.21999

Abstract

Previous studies have identified many genetic loci for refractive error and myopia. We aimed to investigate the effect of these loci on ocular biometry as a function of age in children, adolescents, and adults. The study population consisted of three age groups identified from the international CREAM consortium: 5,490 individuals aged 25 years. All participants had undergone standard ophthalmic examination including measurements of axial length (AL) and corneal radius (CR). We examined the lead SNP at all 39 currently known genetic loci for refractive error identified from genome-wide association studies (GWAS), as well as a combined genetic risk score (GRS). The beta coefficient for associa..

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