Journal article
GM-CSF primes cardiac inflammation in a mouse model of Kawasaki disease
AT Stock, JA Hansen, MA Sleeman, BS McKenzie, IP Wicks
Journal of Experimental Medicine | ROCKEFELLER UNIV PRESS | Published : 2016
DOI: 10.1084/jem.20151853
Abstract
Kawasaki disease (KD) is the leading cause of pediatric heart disease in developed countries. KD patients develop cardiac inflammation, characterized by an early infiltrate of neutrophils and monocytes that precipitates coronary arteritis. Although the early inflammatory processes are linked to cardiac pathology, the factors that regulate cardiac inflammation and immune cell recruitment to the heart remain obscure. In this study, using a mouse model of KD (induced by a cell wall Candida albicans water-soluble fraction [CAWS]), we identify an essential role for granulocyte/macrophage colony-stimulating factor (GMCSF) in orchestrating these events. GM-CSF is rapidly produced by cardiac fibrobl..
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Awarded by National Science Foundation
Funding Acknowledgements
This work was supported by the Australian National Health and Medical Research Council (program grant 1023407 and Clinical Practitioner Fellowship 0123462 to I.P. Wicks), the National Heart Foundation of Australia (grant 1009427 to I.P. Wicks), and the John T. Reid Charitable Trusts.B.S. McKenzie was employed by CSL Limited and is currently employed by Genentech. I.P. Wick's laboratory has received funding from CSL Limited and MedImmune for research on cytokine antagonists. M.A. Sleeman is an employee of MedImmune, a wholly owned subsidiary of AstraZeneca. MedImmune and AstraZeneca have an anti-human GM-CSFR. chain antibody, mavrilimumab, in clinical development. The authors declare no further competing financial interests.