Identification of genes differentially expressed in menstrual breakdown and repair

P Paiva; MG Lockhart; JE Girling; M Olshansky; N Woodrow; JL Marino; M Hickey; PAW Rogers

Journal article

Identification of genes differentially expressed in menstrual breakdown and repair

P Paiva, MG Lockhart, JE Girling, M Olshansky, N Woodrow, JL Marino, M Hickey, PAW Rogers

Molecular Human Reproduction | OXFORD UNIV PRESS | Published : 2016

DOI: 10.1093/molehr/gaw060

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Abstract

STUDY QUESTION: Does the changing molecular profile of the endometrium during menstruation correlate with the histological profile of menstruation.SUMMARY ANSWER: We identified several genes not previously associated with menstruation; on Day 2 of menstruation (early-menstruation), processes related to inflammation are predominantly up-regulated and on Day 4 (late-menstruation), the endometrium is predominantly repairing and regenerating.WHAT IS KNOWN ALREADY: Menstruation is induced by progesterone withdrawal at the end of the menstrual cycle and involves endometrial tissue breakdown, regeneration and repair. Perturbations in the regulation of menstruation may result in menstrual disorders ..

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University of Melbourne Researchers

Jennifer Marino Author

Martha Hickey Author

Peter Rogers Author

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Funding Acknowledgements

Funding for this work was provided by a National Health and Medical Research Council (NHMRC) of Australia Project Grant APP1008553 to M.H., P.R. and J.G. M.H. is supported by an NHMRC Practitioner Fellowship. P.P. is supported by an NHMRC Early Career Fellowship.