Journal article

Evidence of Flicker-Induced Functional Hyperaemia in the Smallest Vessels of the Human Retinal Blood Supply

Angelina Duan, Phillip A Bedggood, Bang V Bui, Andrew B Metha

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2016

Abstract

Regional changes in blood flow are initiated within neural tissue to help fuel local differences in neural activity. Classically, this response was thought to arise only in larger arterioles and venules. However, recently, it has been proposed that a) the smallest vessels of the circulation make a comparable contribution, and b) the response should be localised intermittently along such vessels, due to the known distribution of contractile mural cells. To assess these hypotheses in human neural tissue in vivo, we imaged the retinal microvasculature (diameters 3-28 μm) non-invasively, using adaptive optics, before and after delivery of focal (360 μm) patches of flickering visible light. Our r..

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Grants

Awarded by Australian Research Council (ARC) Discovery Early Career Researcher Award


Awarded by ARC Future Fellowship Award


Awarded by ARC Discovery Project Grant


Funding Acknowledgements

This research was supported by: an Australian Research Council (ARC) Discovery Early Career Researcher Award (DE120101931); an ARC Future Fellowship Award (FT130100388); an ARC Discovery Project Grant (DP0984649), an Australian Postgraduate Award from the Australian Government; an A.E. Rowden White Foundation benevolent bequest, and a Melbourne Neuroscience Institute (MNI) Interdisciplinary Seed Fund award from the University of Melbourne.