Journal article
Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination
AE Mahan, MF Jennewein, T Suscovich, K Dionne, J Tedesco, AW Chung, H Streeck, M Pau, H Schuitemaker, D Francis, P Fast, D Laufer, BD Walker, L Baden, DH Barouch, G Alter
Plos Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2016
Abstract
Antibody effector functions, such as antibody-dependent cellular cytotoxicity, complement deposition, and antibody-dependent phagocytosis, play a critical role in immunity against multiple pathogens, particularly in the absence of neutralizing activity. Two modifications to the IgG constant domain (Fc domain) regulate antibody functionality: changes in antibody subclass and changes in a single N-linked glycan located in the CH2 domain of the IgG Fc. Together, these modifications provide a specific set of instructions to the innate immune system to direct the elimination of antibody-bound antigens. While it is clear that subclass selection is actively regulated during the course of natural in..
View full abstractGrants
Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
This work was supported by the National Institutes of Health/National Institutes of Allergy and Infectious Disease R01 AI 102660-02 and the Bill and Melinda Gates Foundation Center for AIDS Vaccine Discovery (www.cavd.org) OPP 1032817, National Institutes of Health AI078526 and AI096040 (DHB), the Ragon Institute (ragoninstitute.org) (DHB, GA) and by IAVI (full list available at www.iavi.org) with the generous support of USAID and other donors. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of manuscript.