Effects of Oxaliplatin Treatment on the Enteric Glial Cells and Neurons in the Mouse Ileum
Ainsley M Robinson, Vanesa Stojanovska, Ahmed A Rahman, Rachel M McQuade, Paul V Senior, Kulmira Nurgali
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY | SAGE PUBLICATIONS LTD | Published : 2016
Oxaliplatin, currently used for treatment of colorectal and other cancers, causes severe gastrointestinal side effects, including nausea, vomiting, diarrhea, and constipation that are attributed to mucosal damage. However, delayed onset and long-term persistence of these side effects suggest that damage to the enteric nervous system (ENS) regulating physiological function of the gastrointestinal tract may also occur. The ENS comprises myenteric and submucosal neurons and enteric glial cells (EGCs). This study aimed to investigate the effects of oxaliplatin treatment on enteric neurons and EGCs within the mouse ileum. BALB/c mice received repeated intraperitoneal injections of oxaliplatin (3 ..View full abstract
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by a Victoria University Research Support Grant.