Journal article

DrsG from Streptococcus dysgalactiae subsp equisimilis Inhibits the Antimicrobial Peptide LL-37

Danielle Smyth, Ainslie Cameron, Mark R Davies, Celia McNeilly, Louise Hafner, Kadaba S Sriprakash, David J McMillan

Infection and Immunity | AMER SOC MICROBIOLOGY | Published : 2014

Abstract

SIC and DRS are related proteins present in only 4 of the >200 Streptococcus pyogenes emm types. These proteins inhibit complement-mediated lysis and/or the activity of certain antimicrobial peptides (AMPs). A gene encoding a homologue of these proteins, herein called DrsG, has been identified in the related bacterium Streptococcus dysgalactiae subsp. equisimilis. Here we show that geographically dispersed isolates representing 14 of 50 emm types examined possess variants of drsG. However, not all isolates within the drsG-positive emm types possess the gene. Sequence comparisons also revealed a high degree of conservation in different S. dysgalactiae subsp. equisimilis emm types. To examine ..

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University of Melbourne Researchers

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Funding Acknowledgements

This work was supported by funding provided by the National Health and Medical Research Council of Australia, the Australian Infectious Diseases Research Centre, and the University of the Sunshine Coast. The ongoing S. dysgalactiae subsp. equisimilis genome sequencing project is supported by The Wellcome Trust, United Kingdom.