Journal article

Identification of active variants of PARF in human pathogenic group C and group G streptococci leads to an amended description of its consensus motif

Vanessa Barroso, Manfred Rohde, Mark R Davies, Christine M Gillen, D Patric Nitsche-Schmitz, Katrin Dinkla, Gursharan S Chhatwal

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | ELSEVIER GMBH, URBAN & FISCHER VERLAG | Published : 2009

Abstract

Certain streptococcal M proteins bind collagen via an octapeptide motif that is located in their hypervariable N-terminal region. The interaction with this extracellular matrix protein enhances adhesion to the host tissue and thereby facilitates infection. Moreover, it has the side effect of eliciting collagen autoimmune responses, a phenomenon which is also observed in patients with acute rheumatic fever. Therefore, the octapeptide motif was named peptide associated with rheumatic fever (PARF). Only a comprehensive characterization of the collagen-binding M proteins and their collagen-binding motifs will allow the investigation of their associations with certain streptococcal infections and..

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University of Melbourne Researchers