Journal article

Translational Assays for Assessment of Cognition in Rodent Models of Alzheimer's Disease and Dementia

A Shepherd, S Tyebji, AJ Hannan, EL Burrows

JOURNAL OF MOLECULAR NEUROSCIENCE | HUMANA PRESS INC | Published : 2016

Abstract

Cognitive dysfunction appears as a core feature of dementia, which includes its most prevalent form, Alzheimer's disease (AD), as well as vascular dementia, frontotemporal dementia, and other brain disorders. AD alone affects more than 45 million people worldwide, with growing prevalence in aging populations. There is no cure, and therapeutic options remain limited. Gene-edited and transgenic animal models, expressing disease-specific gene mutations, illuminate pathogenic mechanisms leading to cognitive decline in AD and other forms of dementia. To date, cognitive tests in AD mouse models have not been directly relevant to the clinical presentation of AD, providing challenges for translation..

View full abstract

Grants

Awarded by ARC FT3 Future Fellowship


Awarded by NHMRC-ARC Dementia Research Development Fellowship


Funding Acknowledgements

AJH is an NHMRC Senior Research Fellow and has been supported by an ARC FT3 Future Fellowship (FT100100835). ELB is supported by the NHMRC-ARC Dementia Research Development Fellowship (1111552). We would also like to acknowledge the operational infrastructure support from the State Government of Victoria.