Journal article
Altering the course of schizophrenia: Progress and perspectives
MJ Millan, A Andrieux, G Bartzokis, K Cadenhead, P Dazzan, P Fusar-Poli, J Gallinat, J Giedd, DR Grayson, M Heinrichs, R Kahn, MO Krebs, M Leboyer, D Lewis, O Marin, P Marin, A Meyer-Lindenberg, P McGorry, P McGuire, MJ Owen Show all
Nature Reviews Drug Discovery | NATURE PORTFOLIO | Published : 2016
DOI: 10.1038/nrd.2016.28
Abstract
Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its genetic and environmental causes has considerably improved, and their relationship to aberrant patterns of neurodevelopment has become clearer. This raises the possibility that 'disease-modifying' strategies could alter the course to-and of-this debilitating disorder, rather than simply alleviating symptoms. A promising window for course-altering intervention is around the time of the first episode of psychosis, especially in young people at risk of transition to schizophrenia. Indeed, studies performed in both individuals at risk of developing schizophrenia and rodent models for schizophrenia sugge..
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Awarded by National Institute of Mental Health
Funding Acknowledgements
The authors thank M. Soubeyran and J.-M. Rivet for logistical support. They would also like to thank the referees for helpful comments that strengthened the article. This paper has its origins in a small, focused meeting that took place in France in 2013, sponsored by 'Advances in Neuroscience for Medical Innovation'. Sadly, two participants at that meeting recently passed away, G. Bartzokis and P. Patterson, and the authors would like to take this opportunity to remember and pay tribute to them.