Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP

PJ Paul; D Raghu; A-L Chan; T Gulati; L Lambeth; E Takano; MJ Herold; J Hagekyriakou; RL Vessella; C Fedele; M Shackleton; ED Williams; S Fox; S Williams; S Haupt; C Gamell; Y Haupt

Journal article

Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP

PJ Paul, D Raghu, A-L Chan, T Gulati, L Lambeth, E Takano, MJ Herold, J Hagekyriakou, RL Vessella, C Fedele, M Shackleton, ED Williams, S Fox, S Williams, S Haupt, C Gamell, Y Haupt

ONCOGENE | NATURE PUBLISHING GROUP | Published : 2016

DOI: 10.1038/onc.2016.159

University of Melbourne Researchers

Clare Fedele Author The Sir Peter MacCallum Department of Oncology

Mark Shackleton Author Clinical Pathology

Susan Haupt Author Clinical Pathology

Elizabeth Williams Author Surgery - St Vincent's Hospital

Scott Williams Author The Sir Peter MacCallum Department of Oncology

Related Projects (3)

New role for the E3 ligase E6AP in the control of cell motility and invasion

Cell motility and invasion are fundamental process in normal cellular functions, however, when deregulated they can lead to metastatic cance..

A NOVEL APPROACH TO RESTORATION OF TUMOUR SUPPRESSION IN LUNG CANCER

Loss of a tumour suppressor is a key event in every cancer, including lung cancer. Therefore restoration of the expression and/or activity o..

RESTORATION OF TUMOUR SUPPRESSION IN PROSTATE CANCER BY TARGETING THE UBIQUITIN PROTEASOME SYSTEM

Grants

Awarded by NHMRC

Awarded by CCV grant

Awarded by PCFA grant

Funding Acknowledgements

This work was supported by NHMRC project grants (1049179 and 1063389) and NHMRC Fellowship to YH (9628426), NHMRC project grant to MJH (1049720), PCF creativity grant to SW and YH, CCV grant (1085154), VCA Richard Pratt Fellowship in Prostate Cancer Research to CG, the PCFA grant (NDDA-1811) to EW, Pfizer Australia, NHMRC and Veski foundings to MS, and a prostate initiative grant from the Foundation of the Peter MacCallum Cancer Centre. PrEC line was a generous gift from Dr Patrick Humbert and Helen Pearson at Peter MacCallum Cancer Centre.