Journal article
Recovery of White Matter following Pediatric Traumatic Brain Injury Depends on Injury Severity
S Genc, V Anderson, NP Ryan, CB Malpas, C Catroppa, MH Beauchamp, TJ Silk
Journal of Neurotrauma | MARY ANN LIEBERT, INC | Published : 2017
Abstract
Previous studies in pediatric traumatic brain injury (TBI) have been variable in describing the effects of injury severity on white-matter development. The present study used diffusion tensor imaging to investigate prospective sub-acute and longitudinal relationships between early clinical indicators of injury severity, diffusion metrics, and neuropsychological outcomes. Pediatric patients with TBI underwent magnetic resonance imaging (MRI) (n = 78, mean [M] = 10.56, standard deviation [SD] = 2.21 years) at the sub-acute stage after injury (M = 5.55, SD = 3.05 weeks), and typically developing children were also included and imaged (n = 30, M = 10.60, SD = 2.88 years). A sub-set of the patien..
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Funding Acknowledgements
This work was supported by a grant from the Victoria Neurotrauma Initiative, Australia. This research was conducted within the Australian Centre for Child Neuropsychological Studies and Developmental Imaging research groups, Murdoch Childrens Research Institute and the Children's MRI Centre, Royal Children's Hospital, Melbourne, Victoria. It was supported by the Murdoch Childrens Research Institute, The Royal Children's Hospital, The Royal Children's Hospital Foundation, The Department of Paediatrics, The University of Melbourne and the Victorian Government's Operational Infrastructure Support Program.