Journal article
Contribution of GABRG2 Polymorphisms to Risk of Epilepsy and Febrile Seizure: a Multicenter Cohort Study and Meta-analysis
BS Haerian, L Baum, P Kwan, SS Cherny, JG Shin, SE Kim, BG Han, HJ Tan, AA Raymond, CT Tan, Z Mohamed
Molecular Neurobiology | HUMANA PRESS INC | Published : 2016
Abstract
Gamma-aminobutyric acid receptor (GABA-A) is the most common receptor of fast synaptic inhibition in the human brain. Gamma protein encoded by the GABRG2 gene is one of the subunits of the GABA-A receptor, which plays an essential role in the function of this receptor. Several studies have identified various febrile seizure (FS) and epilepsy risk variants of GABRG2 gene in different populations, but some others did not support these results. The aim of this case–control study is to investigate whether GABRG2 polymorphisms contribute to susceptibility for FS and epilepsy in pooled data of three cohorts, from Malaysia (composed of Malay, Chinese, and Indian), Hong Kong, and Korea. Furthermore,..
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Awarded by Research Grants Council, University Grants Committee
Funding Acknowledgements
This study was supported by Malaysian Grants HIR MOHE E000025-20001 and RG 520/13HTM and the Research Grants Council of the Hong Kong Special Administrative Region, China grants HKU7623/08M, HKU7747/07M, and CUHK4466/06M. Korean data was supported in part from the Korea Biobank Project (4851-307) and the Korean Genome and Epidemiology Study (4801-302).