Journal article

Nasal High-Flow Therapy for Primary Respiratory Support in Preterm Infants

Calum T Roberts, Louise S Owen, Brett J Manley, Dag H Froisland, Susan M Donath, Kim M Dalziel, Margo A Pritchard, David W Cartwright, Clare L Collins, Atul Malhotra, Peter G Davis, HIPSTER Trial Investigators

New England Journal of Medicine | MASSACHUSETTS MEDICAL SOC | Published : 2016

Abstract

BACKGROUND: Treatment with nasal high-flow therapy has efficacy similar to that of nasal continuous positive airway pressure (CPAP) when used as postextubation support in neonates. The efficacy of high-flow therapy as the primary means of respiratory support for preterm infants with respiratory distress has not been proved. METHODS: In this international, multicenter, randomized, noninferiority trial, we assigned 564 preterm infants (gestational age, ≥28 weeks 0 days) with early respiratory distress who had not received surfactant replacement to treatment with either nasal high-flow therapy or nasal CPAP. The primary outcome was treatment failure within 72 hours after randomization. Noninfer..

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