Journal article
Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges
N Chevalier, JK Tan, LJ Mason, R Robert, CI McKenzie, F Lim, CH Wong, L Macia, AN Thorburn, BE Russ, SL Masters, CR Mackay
Journal of Autoimmunity | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2016
Abstract
Environmental factors contribute to development of autoimmune diseases. For instance, human autoimmune arthritis can associate with intestinal inflammation, cigarette smoking, periodontal disease, and various infections. The cellular and, molecular pathways whereby such remote challenges might precipitate arthritis or flares remain unclear. Here, we used a transfer model of self-reactive arthritis-inducing CD4+ cells from KRNtg mice that, upon transfer, induce a very mild form of autoinflammatory arthritis in recipient animals. This model enabled us to identify external factors that greatly aggravated disease. We show that several distinct challenges precipitated full-blown arthritis, includ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We thank D. Mathis/C. Benoist for KRNtg mice, A. Mansell for NLRP3<SUP>-/-</SUP> mice, the staff of the Garvan and Monash animal facilities and of Australian Bioresources; the Garvan Australian Cancer Research Foundation (ACRF) Facility for help with genotyping. This work was supported by the National Health and Medical Research Council (C.R.M.), the DFG (CH 818/1-1 and CH 818/1-2 to N.C.), the Fritz-Thyssen-Foundation (20.13.0.114 to N.C.), the European Social Fund and the Ministry of Science, Research, and Arts Baden-Wurttemberg (Margarete von Wrangell Programm to N.C.) and the Research Committee (Forschungskommission) of the Medical Faculty of the University of Freiburg. The authors declare no competing financial interests.