Malignant transformation of oral epithelial dysplasia: A real-world evaluation of histopathologic grading

Abstract

Objective This study describes the predictive value of oral epithelial dysplasia (OED) grading as an indicator for malignant transformation and progression. Study Design The records of an Australian-based pathology laboratory were searched for oral mucosal biopsies with a dysplastic or malignant diagnosis. Examination for an association with progression and malignant transformation without reinterpretation was performed. Analysis was undertaken using hazard ratios and the Fisher exact test. Results A total of 368 patients with a diagnosis of OED were included. Twenty-six patients (7.1%) underwent progression or malignant transformation; the annual malignant transformation rate was 1%. No oth..