Effects of cigarette smoking on cortical thickness in major depressive disorder

N Zorlu; VL Cropley; PK Zorlu; DH Delibas; ZH Adibelli; EP Baskin; ÖS Esen; E Bora; C Pantelis

Journal article

Effects of cigarette smoking on cortical thickness in major depressive disorder

N Zorlu, VL Cropley, PK Zorlu, DH Delibas, ZH Adibelli, EP Baskin, ÖS Esen, E Bora, C Pantelis

Journal of Psychiatric Research | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017

DOI: 10.1016/j.jpsychires.2016.09.009

Abstract

Findings of surface-based morphometry studies in major depressive disorder (MDD) are still inconsistent. Given that cigarette smoking is highly prevalent in MDD and has documented negative effects on the brain, it is possible that some of the inconsistencies may be partly explained by cigarette use. The aim of the current study was to examine the influence of cigarette smoking on brain structure in MDD. 50 MDD patients (25 smokers and 25 non-smokers) and 22 age, education, gender and BMI matched non-smoker healthy controls underwent structural magnetic resonance imaging. Thickness and area of the cortex were measured using surface-based morphometry implemented with Freesurfer (v5.3.0). The n..

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University of Melbourne Researchers

Vanessa Cropley Author

Christos Pantelis Author

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Grants

Awarded by Brain and Behavior Research Foundation

Funding Acknowledgements

There was no involvement of the funding sources in study design, in the collection, analysis, and interpretation of data, nor in the writing of the report and the decision to submit the paper for publication. Prof C. Pantelis was supported by a NHMRC Senior Principal Research Fellowship (628386 & 1105825). VC was supported by a National Health and Medical Research Council (NHMRC) Early Career Fellowship (628880), a Brain and Behavior Research Foundation (NARSAD) Young Investigator Award (21660) and a University of Melbourne MDHS Research Fellowship.