Journal article

Effects of cigarette smoking on cortical thickness in major depressive disorder

Nabi Zorlu, Vanessa Louise Cropley, Pelin Kurtgoz Zorlu, Dursun Hakan Delibas, Zehra Hilal Adibelli, Emel Pasa Baskin, Ozgur Sipahi Esen, Emre Bora, Christos Pantelis

Journal of Psychiatric Research | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017

Abstract

Findings of surface-based morphometry studies in major depressive disorder (MDD) are still inconsistent. Given that cigarette smoking is highly prevalent in MDD and has documented negative effects on the brain, it is possible that some of the inconsistencies may be partly explained by cigarette use. The aim of the current study was to examine the influence of cigarette smoking on brain structure in MDD. 50 MDD patients (25 smokers and 25 non-smokers) and 22 age, education, gender and BMI matched non-smoker healthy controls underwent structural magnetic resonance imaging. Thickness and area of the cortex were measured using surface-based morphometry implemented with Freesurfer (v5.3.0). The n..

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Grants

Awarded by NHMRC Senior Principal Research Fellowship


Awarded by National Health and Medical Research Council (NHMRC) Early Career Fellowship


Awarded by Brain and Behavior Research Foundation (NARSAD) Young Investigator Award


Funding Acknowledgements

There was no involvement of the funding sources in study design, in the collection, analysis, and interpretation of data, nor in the writing of the report and the decision to submit the paper for publication. Prof C. Pantelis was supported by a NHMRC Senior Principal Research Fellowship (628386 & 1105825). VC was supported by a National Health and Medical Research Council (NHMRC) Early Career Fellowship (628880), a Brain and Behavior Research Foundation (NARSAD) Young Investigator Award (21660) and a University of Melbourne MDHS Research Fellowship.