ATF3 is a negative regulator of inflammation in human fetal membranes

Ratana Lim; Gillian Barker; Stella Liong; Caitlyn Nguyen-Ngo; Stephen Tong; Tu'uhevaha Kaitu'u-Lino; Martha Lappas

Journal article

ATF3 is a negative regulator of inflammation in human fetal membranes

Ratana Lim, Gillian Barker, Stella Liong, Caitlyn Nguyen-Ngo, Stephen Tong, Tu'uhevaha Kaitu'u-Lino, Martha Lappas

PLACENTA | W B SAUNDERS CO LTD | Published : 2016

DOI: 10.1016/j.placenta.2016.09.006

Abstract

INTRODUCTION: Infection and inflammation stimulate pro-inflammatory cytokines, prostaglandins and matrix metalloproteinase (MMP)-9, which play a central role in myometrial contractions and rupture of fetal membranes. In human and mouse immune cells, activating transcription factor 3 (ATF3) is a negative regulator of inflammation. No studies have examined the role of ATF3 in human labour. METHODS: Primary amnion cells were used to determine the effect of interleukin (IL)-1β and the bacterial product fibroblast-stimulating lipopeptide (fsl-1) on ATF3 expression, and the effect of ATF3 siRNA on pro-labour mediators. ATF3 expression was assessed in fetal membranes from non-labouring and labourin..

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University of Melbourne Researchers

Tu'uhevaha Kaitu'u-Lino Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Stephen Tong Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Martha Lappas Author Obstetrics and Gynaecology Royal Women's Hospital/Mercy

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Grants

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by NHMRC

Funding Acknowledgements

ML, KT and ST are supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC #1047025, #1050765, #1062418). Funding for this study was provided by the NHMRC (grant no. 1058786), Norman Beischer Medical Research Foundation and the Mercy Research Foundation.