Journal article

Codelivery of NOD2 and TLR9 Ligands via Nanoengineered Protein Antigen Particles for Improving and Tuning Immune Responses

Katelyn T Gause, Yan Yan, Neil M O'Brien-Simpson, Jiwei Cui, Jason C Lenzo, Eric C Reynolds, Frank Caruso

ADVANCED FUNCTIONAL MATERIALS | WILEY-V C H VERLAG GMBH | Published : 2016

Abstract

Vaccine adjuvants that can induce robust protective immunity are highly sought after for the development of safer and more effective vaccines. Vaccine formulation parameters that govern efficacy are still far from clear, such as the diverse impacts of codelivering agonist molecules for innate cell receptors (e.g., pattern recognition receptors). In this study, a mesoporous silica-templating approach is used to fabricate protein antigen (ovalbumin) particles covalently functionalized with agonists for NOD-like receptor 2 (NOD2) and Toll-like receptor 9 (TLR9). Particle-induced combinatorial NOD2/TLR9 signaling results in synergistic inflammatory cytokine secretion by mouse macrophages (RAW 26..

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Grants

Awarded by Australian Research Council (ARC) under Australian Laureate Fellowship


Awarded by Australian Research Council (ARC) under Discovery Early Career Researcher Award


Awarded by ARC Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by National Health and Medical Research Council


Funding Acknowledgements

This work was supported by the Australian Research Council (ARC) under the Australian Laureate Fellowship (F.C., FL120100030), Discovery Early Career Researcher Award (Y.Y., DE130100488), and ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (CE140100036) schemes, as well as a National Health and Medical Research Council Project Grant (APP1029878). K.T.G. acknowledges funding from the Australian Government through an International Postgraduate Research Scholarship and an Australian Postgraduate Award.