A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin
John G Menting, Joanna Gajewiak, Christopher A MacRaild, Danny Hung-Chieh Chou, Maria M Disotuar, Nicholas A Smith, Charleen Miller, Judit Erchegyi, Jean E Rivier, Baldomero M Olivera, Briony E Forbes, Brian J Smith, Raymond S Norton, Helena Safavi-Hemami, Michael C Lawrence
Nature Structural & Molecular Biology | NATURE PUBLISHING GROUP | Published : 2016
Awarded by National Institutes of Health
Awarded by NHMRC
Awarded by European Commission
R.S.N. acknowledges fellowship support from the National Health and Medical Research Council of Australia (NHMRC). N.A.S. acknowledges receipt of an Australian Postgraduate Award scholarship. This work was supported in part by National Institutes of Health grants GM 48677 (to B.M.O. and J.E.R., a subcontractor at Sentia Medical Sciences), by NHMRC Project Grant APP1058233 (to M.C.L.) and by the Utah Science and Technology Initiative (USTAR, to D.H.-C.C.). H.S.-H. acknowledges fellowship support from the European Commission (CONBIOS 330486). Aspects of this work were made possible through Victorian State Government Operational Infrastructure Support, the Australian Government NHMRC IRIISS and a pilot grant from the University of Utah Diabetes and Metabolism Center. We thank A. Morrione (Thomas Jefferson University) for providing cells. Part of this research was undertaken on the MX2 beandine at the Australian Synchrotron (Victoria, Australia).