Metabolic profiling and in vitro assessment of anthelmintic fractions of Picria fel-terrae Lour
Rasika Kumarasingha, Avinash V Karpe, Sarah Preston, Tiong-Chia Yeo, Diana SL Lim, Chu-Lee Tu, Jennii Luu, Kaylene J Simpson, Jillian M Shaw, Robin B Gasser, David J Beale, Paul D Morrison, Enzo A Palombo, Peter R Boag
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE | ELSEVIER SCI LTD | Published : 2016
Anthelmintic resistance is widespread in gastrointestinal nematode populations, such that there is a consistent need to search for new anthelmintics. However, the cost of screening for new compounds is high and has a very low success rate. Using the knowledge of traditional healers from Borneo Rainforests (Sarawak, Malaysia), we have previously shown that some traditional medicinal plants are a rich source of potential new anthelmintic drug candidates. In this study, Picria fel-terrae Lour. plant extract, which has previously shown promising anthelmintic activities, was fractionated via the use of a solid phase extraction cartridge and each isolated fraction was then tested on free-living ne..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
RBG and PRB are funded in part from the National Health and Medical Research Council (NHMRC) of Australia (Grant number 1044022). RK was awarded an Australian Postgraduate Award (APA) from the Australian Government via Monash University and Swinburne University of Technology. The Victorian Centre for Functional Genomics (KJS) was funded by the Australian Cancer Research Foundation (ACRF), the Victorian Department of Industry, Innovation and Regional Development (DIIRD), the Australian Phenomics Network (APN) and supported by funding from the Australian Government's Education Investment Fund through the Super Science Initiative, the Australasian Genomics Technologies Association (AGTA), the Brockhoff Foundation and the Peter Mac-Callum Cancer Centre Foundation.