How host regulation of Helicobacter pylori-induced gastritis protects against peptic ulcer disease and gastric cancer
Poshmaal Dhar, Garrett Z Ng, Philip Sutton
AJP Gastrointestinal and Liver Physiology | AMER PHYSIOLOGICAL SOC | Published : 2016
The bacterial pathogen Helicobacter pylori is the etiological agent of a range of gastrointestinal pathologies including peptic ulcer disease and the major killer, gastric adenocarcinoma. Infection with this bacterium induces a chronic inflammatory response in the gastric mucosa (gastritis). It is this gastritis that, over decades, eventually drives the development of H. pylori-associated disease in some individuals. The majority of studies investigating H. pylori pathogenesis have focused on factors that promote disease development in infected individuals. However, an estimated 85% of those infected with H. pylori remain completely asymptomatic, despite the presence of pathogenic bacteria t..View full abstract
The authors are supported by the Victorian Government's Operational Infrastructure Support Program. P. Sutton is supported by a Senior Research Fellowship from the National Health and Medical Research Council of Australia. P. Dhar is supported by a Victoria India Doctoral Scholarship.