Journal article

How host regulation of Helicobacter pylori-induced gastritis protects against peptic ulcer disease and gastric cancer

Poshmaal Dhar, Garrett Z Ng, Philip Sutton

AJP Gastrointestinal and Liver Physiology | AMER PHYSIOLOGICAL SOC | Published : 2016


The bacterial pathogen Helicobacter pylori is the etiological agent of a range of gastrointestinal pathologies including peptic ulcer disease and the major killer, gastric adenocarcinoma. Infection with this bacterium induces a chronic inflammatory response in the gastric mucosa (gastritis). It is this gastritis that, over decades, eventually drives the development of H. pylori-associated disease in some individuals. The majority of studies investigating H. pylori pathogenesis have focused on factors that promote disease development in infected individuals. However, an estimated 85% of those infected with H. pylori remain completely asymptomatic, despite the presence of pathogenic bacteria t..

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Funding Acknowledgements

The authors are supported by the Victorian Government's Operational Infrastructure Support Program. P. Sutton is supported by a Senior Research Fellowship from the National Health and Medical Research Council of Australia. P. Dhar is supported by a Victoria India Doctoral Scholarship.