Journal article

Comparing nodal versus bony metastatic spread using tumour phylogenies

Stefano Mangiola, Matthew KH Hong, Marek Cmero, Natalie Kurganovs, Andrew Ryan, Anthony J Costello, Niall M Corcoran, Geoff Macintyre, Christopher M Hovens



The role of lymph node metastases in distant prostate cancer dissemination and lethality is ill defined. Patients with metastases restricted to lymph nodes have a better prognosis than those with distant metastatic spread, suggesting the possibility of distinct aetiologies. To explore this, we traced patterns of cancer dissemination using tumour phylogenies inferred from genome-wide copy-number profiling of 48 samples across 3 patients with lymph node metastatic disease and 3 patients with osseous metastatic disease. Our results show that metastatic cells in regional lymph nodes originate from evolutionary advanced extraprostatic tumour cells rather than less advanced central tumour cell pop..

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Awarded by NHMRC

Awarded by CRUK core grant

Funding Acknowledgements

We thank M. Kerger and P. Xibberas for tumour sample collection and patient disease annotation. We thank all members of the CMH laboratory for helpful comments and editing of this manuscript. This work was supported, in part, by NHMRC grants 1047581 and 1104010 to CMH and 1024081 to NMC. The Ovarian Cancer Action [BriTROC project grant: G.M]; The University of Cambridge, Cancer Research UK, Hutchinson Whampoa Limited, CRUK core grant C14303/A17197 (CRUK CI institute core grant, GM).