Reanalysis of the Acid—Base Dissociation Behavior of Dimyristoyldansylcephalin in Dimyristoylmethylphosphatidic Acid Membranes

Abstract

The work of Vaz et al. (Vaz, W. L. C.; Nicksch, A.; Jahnig, F. Eur. J. Biochem. 1978,83, 299) concerning the acid–base dissociation behavior of dimyristoyldansylcephalin in dimyristoylmethylphosphatidic acid (DMPA) membranes has been reanalyzed. The reanalysis has established that the acid-base behavior of dimyristoyldansylcephalin in DMPA membranes is entirely consistent with the prototropic moiety of the dansyl chromophore residing, on average, in the plane of the charged head groups of the DMPA membranes and thus responding to induced changes in the electrostatic surface potential of the membranes. © 1987, American Chemical Society. All rights reserved.