Journal article

Primary open-angle glaucoma

Robert N Weinreb, Christopher KS Leung, Jonathan G Crowston, Felipe A Medeiros, David S Friedman, Janey L Wiggs, Keith R Martin

Nature Reviews Disease Primers | NATURE PUBLISHING GROUP | Published : 2016


Glaucoma is an optic neuropathy that is characterized by the progressive degeneration of the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible blindness worldwide, but typically remains asymptomatic until very severe. Open-angle glaucoma comprises the majority of cases in the United States and western Europe, of which, primary open-angle glaucoma (POAG) is the most common type. By contrast, in China and other Asian countries, angle-closure glaucoma is highly prevalent. These two types of glaucoma are characterized based on the anatomic configuration of the aqueous humour outflow pathway. The pathophysiology of POAG is not well understood, but it is an opti..

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Funding Acknowledgements

R.N.W. has received research support from the National Eye Institute. D.S.F. has received research support from the US NIH and the US Centers of Disease Control and Prevention. J.L.W. has received research support from the NIH, March of Dimes and Research to Prevent Blindness.