Preparation and In Vitro Release of Drug-Loaded Microparticles for Oral Delivery Using Wholegrain Sorghum Kafirin Protein
Esther TL Lau, Stuart K Johnson, Roger A Stanley, Deirdre Mikkelsen, Zhongxiang Fang, Peter J Halley, Kathryn J Steadman
INTERNATIONAL JOURNAL OF POLYMER SCIENCE | HINDAWI LTD | Published : 2015
Kafirin microparticles have been proposed as an oral nutraceutical and drug delivery system. This study investigates microparticles formed with kafirin extracted from white and raw versus cooked red sorghum grains as an oral delivery system. Targeted delivery to the colon would be beneficial for medication such as prednisolone, which is used in the management of inflammatory bowel disease. Therefore, prednisolone was loaded into microparticles of kafirin from the different sources using phase separation. Differences were observed in the protein content, in vitro protein digestibility, and protein electrophoretic profile of the various sources of sorghum grains, kafirin extracts, and kafirin ..View full abstract
Awarded by Australian Government Department of Innovation, Industry Science and Research Indo-Australian Biotechnology Fund
The authors thank Mridusmita Chaliha (Department of Agriculture, Fisheries and Forestry, Brisbane) for technical support with kafirin extractions, Paul Dubois and Jiayue Chu (Curtin University) for technical assistance, and the Australian Government Department of Innovation, Industry Science and Research Indo-Australian Biotechnology Fund (BF040035), Curtin University, and The University of Queensland for financial support; and the Queensland Government Smart Futures initiative for top-up scholarship funding to Esther T. L. Lau. The authors also acknowledge Australian Microscopy & Microanalysis Research Facility at the Centre for Microscopy and Microanalysis, The University of Queensland.