Journal article

Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: a characterization study

Armin Mooranian, Rebecca Negrulj, Nigel Chen-Tan, Hesham S Al-Sallami, Zhongxiang Fang, Trilochan Mukkur, Momir Mikov, Svetlana Golocorbin-Kon, Marc Fakhoury, Frank Arfuso, Hani Al-Salami

Drug Design, Development and Therapy | DOVE MEDICAL PRESS LTD | Published : 2014

Abstract

Gliclazide (G) is an antidiabetic drug commonly used in type 2 diabetes. It has extrapancreatic hypoglycemic effects, which makes it a good candidate in type 1 diabetes (T1D). In previous studies, we have shown that a gliclazide-bile acid mixture exerted a hypoglycemic effect in a rat model of T1D. We have also shown that a gliclazide-deoxycholic acid (G-DCA) mixture resulted in better G permeation in vivo, but did not produce a hypoglycemic effect. In this study, we aimed to develop a novel microencapsulated formulation of G-DCA with uniform structure, which has the potential to enhance G pharmacokinetic and pharmacodynamic effects in our rat model of T1D. We also aimed to examine the effec..

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University of Melbourne Researchers