A novel regulatory relationship between RIPK4 and ELF3 in keratinocytes
Glen M Scholz, Nur S Sulaiman, Sahar Al Baiiaty, Mei Qi Kwa, Eric C Reynolds
CELLULAR SIGNALLING | ELSEVIER SCIENCE INC | Published : 2016
Keratinocytes are central to the barrier functions of surface epithelia, such as the gingiva and epidermis. RIPK4 is a key regulator of keratinocyte differentiation; however, the signalling pathways in which it functions remain poorly defined. In this study, we identified a regulatory relationship between RIPK4 and ELF3, an ETS family transcription factor. RIPK4 was shown to be important for the upregulation of ELF3 gene expression by the PKC agonist PMA in both oral and epidermal keratinocytes. RIPK4 promotes keratinocyte differentiation in part by phosphorylating and thereby activating the IRF6 transcription factor. Significantly, silencing of IRF6 inhibited the PMA-inducible expression of..View full abstract
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Awarded by National Health and Medical Research Council
This research was supported by the Australian Government, Department of Industry, Innovation and Science, and National Health and Medical Research Council Project Grant 628769.