Journal article

A Functional Role for Antibodies in Tuberculosis

Lenette L Lu, Amy W Chung, Tracy R Rosebrock, Musie Ghebremichael, Wen Han Yu, Patricia S Grace, Matthew K Schoen, Fikadu Tafesse, Constance Martin, Vivian Leung, Alison E Mahan, Magdalena Sips, Manu P Kumar, Jacquelynne Tedesco, Hannah Robinson, Elizabeth Tkachenko, Monia Draghi, Katherine J Freedberg, Hendrik Streeck, Todd J Suscovich Show all

Cell | CELL PRESS | Published : 2016

University of Melbourne Researchers


Awarded by NIH

Awarded by DARPA

Awarded by Harvard University Center for AIDS Research (CFAR)

Awarded by NHMRC

Awarded by Bill and Melinda Gates Foundation CAVD (Leveraging Antibody Effector Function)


Funding Acknowledgements

CEM.NKR-CCR5 was obtained through the AIDS Research and Reference Reagent Program, Division of AIDS, NIAID, NIH. The following reagents were obtained through BEI Resources, NIAID, NIH: cell membrane, culture filtrate, cytosol protein, soluble cell wall protein, and soluble protein fractions of H37RV M. tuberculosis. We thank Peter Sorger for access to the Operetta High-Content Imaging Fluorescence Microscope; Rebecca Gelman, Director of the Harvard Center for AIDS Biostatistics Core, for her advice; and many additional members of the SATVI team who helped with enrollment and evaluation of participants. This work was supported by the NIH (grants R01 AI080289 and AI102660, to G.A.), Dr. Dan Wattendorf and DARPA BAA-11-65 (G.A.), Harvard University Center for AIDS Research (CFAR) grant P30 AI060354 (to G.A., S.M.F., T.R., and M.G., Ragon BL3 and Imaging Core Facility), grant T32 AI007387 (to L.L.L.), NHMRC APP1036470 (A.W.C.), Bill and Melinda Gates Foundation CAVD (OPP1032817: Leveraging Antibody Effector Function) (G.A.), the Pozen Family Foundation (S.M.F.), the Doris Duke Medical Research Foundation (S.M.F.), the Burroughs Wellcome Foundation (S.M.F.), and the Ragon Institute of MGH, MIT, and Harvard.