Journal article

Streamlined genetic education is effective in preparing women newly diagnosed with breast cancer for decision making about treatment-focused genetic testing: a randomized controlled noninferiority trial

Veronica F Quinn, Bettina Meiser, Judy Kirk, Kathy M Tucker, Kaaren J Watts, Belinda Rahman, Michelle Peate, Christobel Saunders, Elizabeth Geelhoed, Margaret Gleeson, Kristine Barlow-Stewart, Michael Field, Marion Harris, Yoland C Antill, Linda Cicciarelli, Karen Crowe, Michael T Bowen, Gillian Mitchell



PURPOSE: Increasingly, women newly diagnosed with breast cancer are being offered treatment-focused genetic testing (TFGT). As the demand for TFGT increases, streamlined methods of genetic education are needed. METHODS: In this noninferiority trial, women aged <50 years with either a strong family history (FH+) or other features suggestive of a germ-line mutation (FH-) were randomized before definitive breast cancer surgery to receive TFGT education either as brief written materials (intervention group (IG)) or during a genetic counseling session at a familial cancer clinic (usual-care group (UCG)). Women completed self-report questionnaires at four time points over 12 months. RESULTS: A tot..

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Awarded by National Breast Cancer Foundation

Awarded by Career Development Fellowship Award Level 2

Awarded by Senior Research Fellowship Level B from the National Health and Medical Research Council Australia

Awarded by Early Career Fellowship from the National Breast Cancer Foundation

Funding Acknowledgements

This trial was funded by a Priority-Driven Collaborative Research Grant that was jointly supported by Cancer Australia, Cancer Council Australia, and the National Breast Cancer Foundation (630405). B.M. was supported by a Career Development Fellowship Award Level 2 (1003921) and a Senior Research Fellowship Level B (1078523) from the National Health and Medical Research Council Australia. M.P. is currently supported by an Early Career Fellowship (ECF-15-005) from the National Breast Cancer Foundation. The authors thank the patients who participated in this study, as well as the members of the TFGT Collaborative Group and the recruiting surgeons and staff involved at participating familial cancer clinics. The authors also gratefully acknowledge the assistance of the other health professionals and staff who were involved at each site. In addition, the authors thank Emma Healey for the calculation of BOADICEA scores, Mariana De Souza for research assistance, and Patrick Kelly, Gillian Heller, Val Gebski, and Ian Marschner for statistical advice. Finally, the authors acknowledge the support and endorsement of this project by the Psycho-oncology Cooperative Research Group (PoCoG). TFGT Collaborative Group: The additional members of the Treatment Focused Genetic Testing Collaborative Group are, in alphabetical order by group or institution: Cabrini Health-Melbourne (P. Gregory, L. Lipton, L. McKay, J. Senior); Calvary Centre for Palliative Care, Sydney (L. Lobb); Department of Medical Oncology, Prince of Wales Hospital (P. Crowe, A. Matthews, G. Neil, A. Parasyn, D. Thomson); Hereditary Cancer Clinic, Prince of Wales Hospital, Sydney (J. Duffy, L. Andrews, J. Gale); Monash Medical Centre, Melbourne (J. Fox, S. Hart, C. Smythe, M. White); Nam-bour Hospital, Nambour (L. Creighton, J. D'arcy, S. Grieve, E. Secomb); Peter MacCallum Cancer Centre, Melbourne (M. Henderson, J. O'Brien, C. Poliness); Royal Brisbane Hospital (A. Hat-tam, R. Susman, O. Ung,); Royal North Shore Hospital, Sydney (R. Dickson, K. Moore); St George Hospital, Sydney (P. Bastick, S. Inder, J. Lynch, P. Schwartz, R. Zia); The Poche Centre, Sydney (C. Mak, K. Snook, A. Spillane); University of Melbourne (J. Hopper); Westmead Hospital, Sydney (M. Bowman, D. Cheung, S. Edirimanne, E. Edwards, E. Elder, J. French, D. Moon).