Lipid structure influences the ability of glucose monocorynomycolate to signal through Mincle
Phillip L van der Peet, Masahiro Nagata, Sayali Shah, Jonathan M White, Sho Yamasaki, Spencer J Williams
ORGANIC & BIOMOLECULAR CHEMISTRY | ROYAL SOC CHEMISTRY | Published : 2016
Mincle (macrophage-inducible C-type lectin) is a C-type lectin receptor that provides the capacity for immune sensing of a range of pathogen- and commensal-derived glycolipids. Mincle can recognize mycolic and/or corynomycolic acid esters of trehalose, glycerol and glucose from mycobacteria and corynebacteria. While simple straight-chain long fatty acids (e.g. behenic acid) can substitute for mycolic acid on trehalose and glycerol and maintain robust signalling through Mincle, glucose monobehenate has been reported to be much less active than glucose monocorynomycolate (GMCM). We report the preparation of a range of analogues of GMCM to explore structural requirements in the lipid chain for ..View full abstract
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Awarded by MEXT
Awarded by Grants-in-Aid for Scientific Research
Funding was provided by the Australian Research Council, a JSPS Grant-in-Aid for Scientific Research, a Grant-in-Aid for Scientific Research on Innovative Areas (26110009) from MEXT, and Grants from MHLW and the Research on Development of New Drugs, AMED. SS thanks the Department of State Development, Business and Innovation of Victoria for a Victoria-India Doctoral Scholarship and the Australia India Institute.