Journal article
Efficacy and safety of liraglutide added to insulin treatment in type 1 diabetes: The adjunct one treat-to-target randomized trial
C Mathieu, B Zinman, JU Hemmingsson, V Woo, P Colman, E Christiansen, M Linder, B Bode
Diabetes Care | AMER DIABETES ASSOC | Published : 2016
DOI: 10.2337/dc16-0691
Abstract
OBJECTIVE To investigate whether liraglutide added to treat-to-target insulin improves glycemic control and reduces insulin requirements and body weight in subjects with type 1 diabetes. RESEARCH DESIGN AND METHODS A 52-week, double-blind, treat-to-target trial involving 1,398 adults randomized 3:1 to receive once-daily subcutaneous injections of liraglutide (1.8, 1.2, or 0.6 mg) or placebo added to insulin. RESULTS HbA1c level was reduced 0.34-0.54% (3.7-5.9 mmol/mol) from a mean baseline of 8.2% (66 mmol/mol), and significantly more for liraglutide 1.8 and 1.2 mg compared with placebo (estimated treatment differences [ETDs]: 1.8 mg liraglutide 20.20% [95% CI 20.32; 20.07]; 1.2 mg liragluti..
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Funding Acknowledgements
The authors thank all subjects and ADJUNCT ONE investigators involved in the study. The authors also thank Salvatore Calanna and Thomas Jon Jensen of Novo Nordisk A/S for their review and input to the manuscript and Daniel Hayward of Novo Nordisk A/S for providing medical writing assistance during the preparation of this manuscript. Submission support was provided by Watermeadow Medical, an Ashfield Company, part of UDG Healthcare plc, funded by Novo Nordisk.