OS 31-01 BLOOD PRESSURE, INITIAL ORTHOSTATIC HYPOTENSION, GLYCERYL TRINITRATE AND THE GLU504LYS POLYMORPHISM OF ALDEHYDE DEHYROGENASE-2.
S Harrap, A Lamantia, J Ziogas, J Bourke
J Hypertens | Published : 2016
OBJECTIVE: Glyceryl trinitrate (GTN) is used to treat angina and lower blood pressure. The enzyme mitochondrial aldehyde dehydrogenase-2 (ALDH2) can activate GTN. The polymorphism (Gly504Lys) in the gene encoding ALDH2 is associated with significantly reduced enzyme activity and potentially diminished responses to GTN. DESIGN AND METHOD: Systolic blood pressure (SBP) was measured continuously (Finometer Midi) during 2 orthostatic challenges in 493 healthy young adults (mean age 22 y), 390 of whom took 300 μg GTN sublingually 5 min prior to the second challenge and 103 subjects of whom were untreated. We recorded the average SBP for 30 s after 5 minutes lying, the nadir in SBP within 30 s of ..View full abstract