Journal article

Stimulation of a Suprachoroidal Retinal Prosthesis Drives Cortical Responses in a Feline Model of Retinal Degeneration

Felix P Aplin, Erica L Fletcher, Chi D Luu, Kirstan A Vessey, Penelope J Allen, Robyn H Guymer, Robert K Shepherd, Mohit N Shivdasani

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2016

Abstract

Purpose: Retinal prostheses have emerged as a promising technology to restore vision in patients with severe photoreceptor degeneration. To better understand how neural degeneration affects the efficacy of electronic implants, we investigated the function of a suprachoroidal retinal implant in a feline model. Methods: Unilateral retinal degeneration was induced in four adult felines by intravitreal injection of adenosine triphosphate (ATP). Twelve weeks post injection, animals received suprachoroidal electrode array implants in each eye, and responses to electrical stimulation were obtained using multiunit recordings from the visual cortex. Histologic measurements of neural and glial changes..

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Grants

Awarded by National Health and Medical Research Council project grants by Retina Australia


Funding Acknowledgements

Supported by the Australian Research Council through its Special Research Initiative in Bionic Vision Science and Technology grant to Bionic Vision Australia and by National Health and Medical Research Council project grants (APP1021042; APP1061419) (ELF) by Retina Australia. The Bionics Institute and Center for Eye Research Australia receive Operational Infrastructure Support from the Victoria Government.