Journal article
Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women
P Requena, E Rui, N Padilla, FE Martínez-Espinosa, ME Castellanos, C Bôtto-Menezes, A Malheiro, M Arévalo-Herrera, S Kochar, SK Kochar, DK Kochar, AJ Umbers, M Ome-Kaius, R Wangnapi, D Hans, M Menegon, F Mateo, S Sanz, M Desai, A Mayor Show all
Plos Neglected Tropical Diseases | Published : 2016
Open access
Abstract
P. vivax infection during pregnancy has been associated with poor outcomes such as anemia, low birth weight and congenital malaria, thus representing an important global health problem. However, no vaccine is currently available for its prevention. Vir genes were the first putative virulent factors associated with P. vivax infections, yet very few studies have examined their potential role as targets of immunity. We investigated the immunogenic properties of five VIR proteins and two long synthetic peptides containing conserved VIR sequences (PvLP1 and PvLP2) in the context of the PregVax cohort study including women from five malaria endemic countries: Brazil, Colombia, Guatemala, India and..
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Awarded by European Commission
Funding Acknowledgements
The PREGVAX project received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement 201588, and co-funding from the Ministerio de Economia y Competitividad (National R&D Internationalisation Programme, EUROSALUD 2008, Spain) under grant agreement EUS2009-03560. The Latin American sites received co-funding from the CDC Foundation, who received a grant from the Malaria in Pregnancy Consortium (MiPc) which is partially funded through a grant from the Bill & Melinda Gates Foundation to the Liverpool School of Tropical Medicine (46099). The studies in PNG also received co-funding from the MiPc. CD was supported by a fellowship from the Ministerio de Economia y Competitividad (RYC-2008-02631), AMay was supported by Institute de Salud Carlos III (CES10/021-I3SNS) and IM was supported by a National Health and Medical Research Council Senior Research Fellowship (GNT1043345). CD and HdP were affiliate and full member, respectively, of the EU FP7 Network of Excellence EviMalaR. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.