Journal article

A novel approach to identifying patterns of human invasion-inhibitory antibodies guides the design of malaria vaccines incorporating polymorphic antigens

Damien R Drew, Danny W Wilson, Salenna R Elliott, Nadia Cross, Ulrich Terheggen, Anthony N Hodder, Peter M Siba, Kiprotich Chelimo, Arlene E Dent, James W Kazura, Ivo Mueller, James G Beeson

BMC MEDICINE | BIOMED CENTRAL LTD | Published : 2016

Abstract

BACKGROUND: The polymorphic nature of many malaria vaccine candidates presents major challenges to achieving highly efficacious vaccines. Presently, there is very little knowledge on the prevalence and patterns of functional immune responses to polymorphic vaccine candidates in populations to guide vaccine design. A leading polymorphic vaccine candidate against blood-stage Plasmodium falciparum is apical membrane antigen 1 (AMA1), which is essential for erythrocyte invasion. The importance of AMA1 as a target of acquired human inhibitory antibodies, their allele specificity and prevalence in populations is unknown, but crucial for vaccine design. METHODS: P. falciparum lines expressing diffe..

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Grants

Awarded by National Health and Medical Research Council of Australia (Peter Doherty Australian Biomedical Fellowship)


Awarded by National Institutes of Health


Awarded by National Institutes of Health (International Centers of Excellence in Malaria Research Program)


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This work was supported by the PATH Malaria Vaccine Initiative, the United States Agency for International Development (USAID), National Health and Medical Research Council of Australia (Program Grant to JGB; Senior research fellowship to JGB; Peter Doherty Australian Biomedical Fellowship to DWW (APP1035715); and Infrastructure for Research Institutes Support Scheme Grant); National Institutes of Health (R01AI095192 and International Centers of Excellence in Malaria Research Program U19A089686); the Victorian State Government Operational Infrastructure Support.