Journal article

The association between higher maternal pre-pregnancy body mass index and increased birth weight, adiposity and inflammation in the newborn

K McCloskey, A-L Ponsonby, F Collier, K Allen, MLK Tang, JB Carlin, R Saffery, MR Skilton, M Cheung, S Ranganathan, T Dwyer, D Burgner, P Vuillermin

Pediatric Obesity | WILEY | Published : 2018

Abstract

BACKGROUND: Excess adiposity and adiposity-related inflammation are known risk factors for cardiovascular disease in adults; however, little is known regarding the determinants of adiposity-related inflammation at birth. OBJECTIVES: The aim of this study was to investigate the association between maternal pre-pregnancy BMI and newborn adiposity and inflammation. METHODS: Paired maternal (28-week gestation) and infant (umbilical cord) blood samples were collected from a population-derived birth cohort (Barwon Infant Study, n = 1074). Data on maternal comorbidities and infant birth anthropomorphic measures were compiled, and infant aortic intima-media thickness was measured by trans-abdominal ..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Health and Medical Research Council (Australia)


Awarded by National Heart Foundation of Australia


Funding Acknowledgements

The authors would like to acknowledge the fieldwork and laboratory team, as well as the participants of the Barwon Infant Study for their ongoing support. The initial establishment work and infrastructure for the BIS was supported by the Murdoch Childrens Research Institute and Barwon Health. Deakin University is now a partner organization and has provided funding and infrastructure. Funding has been provided by the National Health and Medical Research Council of Australia (607370, 1009044, 102997, 1082037, 1076667 and 1084017), the Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, the Our Women's Our Children's Fundraising Committee Barwon Health, the Rotary Club of Geelong, the Shepherd Foundation, the Victorian Government's Operational Infrastructure Support Programme, and the Ilhan Foundation. Kate McCloskey is funded by a Sidney Myer Scholarship. David Burgner is supported by National Health and Medical Research Council (Australia) Fellowship (APP1064629) and is an Honorary Future Leader Fellow of the National Heart Foundation of Australia. Research at Murdoch Childrens Research Institute is supported by the Victorian Government's Operational Infrastructure Support Programme. Michael Skilton is supported by a Future Leader fellowship from the National Heart Foundation of Australia (#100419)